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Article

Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism.

Social cognitive and affective neuroscience - 1 Mar 2017

Watanabe Takamitsu, Otowa Takeshi, Abe Osamu, Kuwabara Hitoshi, Aoki Yuta, Natsubori Tatsunobu, Takao Hidemasa, Kakiuchi Chihiro, Kondo Kenji, Ikeda Masashi, Iwata Nakao, Kasai Kiyoto, Sasaki Tsukasa, Yamasue Hidenori

Abstract excerpt

Oxytocin appears beneficial for autism spectrum disorder (ASD), and more than 20 single-nucleotide polymorphisms (SNPs) in oxytocin receptor (OXTR) are relevant to ASD. However, neither biological functions of OXTR SNPs in ASD nor critical OXTR SNPs that determine oxytocin's effects on ASD remains known. Here, using a machine-learning algorithm that was designed to evaluate collective effects of multiple SNPs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27798253
DOI: 10.1093/scan/nsw150
PMCID: PMC5390696

Genes

OXTR

Provenance

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