Article
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010
Tost Heike, Kolachana Bhaskar, Hakimi Shabnam, Lemaitre Herve, Verchinski Beth A, Mattay Venkata S, Weinberger Daniel R, Meyer-Lindenberg Andreas
Abstract excerpt
The evolutionarily highly conserved neuropeptide oxytocin is a key mediator of social and emotional behavior in mammals, including humans. A common variant (rs53576) in the oxytocin receptor gene (OXTR) has been implicated in social-behavioral phenotypes, such as maternal sensitivity and empathy, and with neuropsychiatric disorders associated with social impairment, but the intermediate neural mechanisms are...
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