Article

Augmenting Transcriptome Annotations through the Lens of Splicing Evolution

2024-11-06

Abstract excerpt

Alternative splicing (AS) is a ubiquitous mechanism in eukaryotes. It is estimated that 90% of human genes are alternatively spliced. Despite enormous efforts, transcriptome annotations remain, nevertheless, incomplete. Conventional means of annotation were largely driven by experimental data such as RNA-seq and protein sequences, while little insight was shed on understanding transcriptomes and alternative splici...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93ae9919-0ddd-558f-91e1-489a37cd1147
DOI: 10.1101/2024.11.04.621892

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Augmenting Transcriptome Annotations through the Lens of Splicing EvolutionDOI 10.1101/2024.11.04.621892Read

Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissuesSemantic proximity Read

<i>SplAdder</i> : Identification, quantification and testing of alternative splicing events from RNA-Seq dataSemantic proximity Read

TRAWLING: a Transcriptome Reference Aware of spLIciNG eventsSemantic proximity Read

Assessing Conservation of Alternative Splicing with Evolutionary Splicing GraphsSemantic proximity Read

A transcript perspective on evolution.Semantic proximity Read

ASTA-P: a pipeline for the detection, quantification and statistical analysis of complex alternative splicing eventsSemantic proximity Read

Self-supervised learning on millions of pre-mRNA sequences improves sequence-based RNA splicing predictionSemantic proximity Read

Highly accurate isoform identification for the human transcriptomeSemantic proximity Read

Detection of alternative splicing: deep sequencing or deep learning?Semantic proximity Read

Leveraging transcript quantification for fast computation of alternative splicing profilesSemantic proximity Read

Revealing missing isoforms encoded in the human genome by integrating genomics, transcriptomics and proteomics dataSemantic proximity Read

Alternative splicing as a source of phenotypic diversity.Semantic proximity Read