Article

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

2022-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited. We therefore performed whole genome sequencing (WGS) on a large cohort of HLHS patients and their families to identify candidate genes that were then tested in Drosophila heart...

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Literature Corpus work: 93aaca01-6c2b-5803-b9a6-7accbdfb4be7
DOI: 10.1101/2022.06.13.22276366

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