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BET inhibitors synergize with anti-PD1 by rescuing TCF1 <sup>+</sup> progenitor exhausted CD8 <sup>+</sup> T cells in Acute Myeloid Leukemia

2021-08-04

Abstract excerpt

Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such as increased myeloid derived suppressor cells (MDSCs), suppressive regulatory T cells (Tregs) and dysfunctional T cells. We have developed a mouse model of AML driven by Flt3-ITD and Tet2 deficiency displays these immune-related features, including CD8 + T cells exhibiting a terminally exhausted phenotype (TEx). This T cell s...

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Identifiers and source

Literature Corpus work
9372efed-67ac-5b5f-956a-88ebe35e5eca
DOI
10.1101/2021.08.04.455147
Open publication

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BET inhibitors synergize with anti-PD1 by rescuing TCF1 <sup>+</sup> progenitor exhausted CD8 <sup>+</sup> T cells in Acute Myeloid LeukemiaDOI 10.1101/2021.08.04.455147
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