Article

Targeted inhibition of ATP synthase subunit c by pp10-loaded inhalable albumin nanoparticles ameliorates airway inflammation in asthma

2026-01-23

Abstract excerpt

<title>Abstract</title> <p>The persistent opening of the mitochondrial permeability transition pore (mPTP) plays a critical role in bronchial asthma pathogenesis. The ATP synthase c subunit (c subunit) constitutes a core component of mPTP. A novel c subunit inhibitor, 1,3,8-triazaspiro [4.5] decane derivatives (PP10), effectively suppresses pathological mPTP opening without impairing ATP synthesis. Although intra...

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Literature Corpus work: 936dfdf8-217a-5e20-8137-fc98a579fde5
DOI: 10.21203/rs.3.rs-8621332/v1

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