Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people

9 Aug 2022

Abstract excerpt

The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2-specific T cell response....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35943812
DOI: 10.1172/jci.insight.161045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged peoplePMID 35943812Read ↗

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responsesSemantic proximity Read ↗

Three doses of Sars-CoV-2 mRNA vaccine in older adults result in similar antibody responses but reduced cellular cytokine responses relative to younger adultsSemantic proximity Read ↗

Impact of BNT162b first vaccination on the immune transcriptome of elderly patients infected with the B.1.351 SARS-CoV-2 variantSemantic proximity Read ↗

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.SSemantic proximity Read ↗

MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccineSemantic proximity Read ↗

Age-related heterogeneity in immune responses to SARS-CoV-2 following BNT162b2 vaccinationSemantic proximity Read ↗

Age-related heterogeneity in immune responses to SARS-CoV-2 vaccine BNT162b2Semantic proximity Read ↗

Induction of immune response after SARS-CoV-2 mRNA BNT162b2 vaccination in healthcare workersSemantic proximity Read ↗

Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and - experienced subjectsSemantic proximity Read ↗

Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccinationSemantic proximity Read ↗

Impact of BNT162b First Vaccination on the Immune Transcriptome of Elderly Patients Infected with the B.1.351 SARS-CoV-2 VariantSemantic proximity Read ↗

Systems biological assessment of human immunity to BNT162b2 mRNA vaccinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.