Article

Baseline Enrichment of T and NK Cell Genes Predispose to mRNA Vaccine-Associated Systemic Adverse Events that Can Be Alleviated by Altering the Route of Vaccination

2021-12-14

Abstract excerpt

Ensuring high vaccination and even booster vaccination coverage are critical in controlling the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the emergence of new genetic variants. Amongst the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectiveness. However, systemic adverse events, such as fatigue, are prevalent following mRNA vaccination and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26cd9410-872f-5b93-ae4c-a32596cb1066
DOI: 10.2139/ssrn.3985604

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Baseline Enrichment of T and NK Cell Genes Predispose to mRNA Vaccine-Associated Systemic Adverse Events that Can Be Alleviated by Altering the Route of VaccinationDOI 10.2139/ssrn.3985604Read

Adverse effects following anti–COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genesSemantic proximity Read

Systems biological assessment of human immunity to BNT162b2 mRNA vaccinationSemantic proximity Read

BNT162b2 mRNA vaccine-induced sex differences in the single-cell transcriptome of peripheral blood mononuclear cells in healthy adultsSemantic proximity Read

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.SSemantic proximity Read

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responsesSemantic proximity Read

Shared Clinical and Immunologic Features of mRNA Vaccines: Preliminary Results from a Comparative Clinical StudySemantic proximity Read

Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus InfectionSemantic proximity Read

Induction of immune response after SARS-CoV-2 mRNA BNT162b2 vaccination in healthcare workersSemantic proximity Read

Systemic IL-15, IFN-γ and IP-10/CXCL10 Signature Associated With Effective Immune Response in BNT162b2 mRNA Vaccine RecipientsSemantic proximity Read

Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccinesSemantic proximity Read

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged peopleSemantic proximity Read

Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infectionSemantic proximity Read