Article

Ancient regulatory evolution shapes individual language abilities in present-day humans

2025-03-11

Abstract excerpt

Language is a defining feature of our species, yet the genomic changes enabling it remain poorly understood. Despite decades of work since FOXP2 ’s discovery, we still lack a clear picture of which regions shaped language evolution and how variation contributes to present-day phenotypic differences. Using a novel evolutionary stratified polygenic score approach in nearly 40,000 individuals, we find that Human Anc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92a21a33-08b7-54fc-ab79-e086f2fc265c
DOI: 10.1101/2025.03.07.641231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ancient regulatory evolution shapes individual language abilities in present-day humansDOI 10.1101/2025.03.07.641231Read

No Evidence for Recent Selection at FOXP2 among Diverse Human Populations.Semantic proximity Read

Fixed human pangenome sequences reveal origins of common human traitsSemantic proximity Read

FOXP2 variation in great ape populations offers insight into the evolution of communication skills.Semantic proximity Read

Evolution is in the details: Regulatory differences in modern human and NeanderthalSemantic proximity Read

Genes and vocal learning.Semantic proximity Read

Human-specific changes in two functional enhancers of <i>FOXP2</i>Semantic proximity Read

Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expressionSemantic proximity Read

Insights into the genetic foundations of human communication.Semantic proximity Read

Long-range regulatory effects of Neandertal DNA in modern humansSemantic proximity Read

Human brain evolution: from gene discovery to phenotype discovery.Semantic proximity Read

Genes Affecting Vocal and Facial Anatomy Went Through Extensive Regulatory Divergence in Modern HumansSemantic proximity Read

The cis-regulatory effects of modern human-specific variants.Semantic proximity Read