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Article

Maternal Opioid Exposure Culminates in Perturbed Murine Neurodevelopment and Hyperactive Phenotype in Adolescence.

Neuroscience - 21 May 2021

Schlagal Caitlin R, Dunn Tiffany J, Xu Pei, Felsing Daniel E, Merritt Christina R, Manja Sanjana, Fox Robert G, Buffington Shelly A, Saade George, Dineley Kelly T, Yu Yongjia, Cunningham Kathryn A, Wu Ping

Abstract excerpt

Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and other long-term neurological deficits. However, the mechanisms underlying the impact of prenatal opioid exposure on fetal neurodevelopment are largely unknown. To translate from the clinical presentation, we developed a novel mouse model to...

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Identifiers

PMID: 33811940
DOI: 10.1016/j.neuroscience.2021.03.014
PMCID: PMC9233450

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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