Article

Competition against the intestinal microbiota selects for pathoadaptive traits in ESBL E. coli

2026-06-29

Abstract excerpt

The intestinal tract is a reservoir for Extended-Spectrum β-Lactamase (ESBL)-producing Escherichia coli. Asymptomatic gut colonization by these pathobionts represents a major risk for extraintestinal infections. Despite clinical relevance, the genetic basis of gut colonization by ESBL E. coli remains poorly understood. Here, we determined how the microbiota shapes the fitness landscape of diverse ESBL E. coli stra...

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Literature Corpus work: 92162cd3-0618-52d8-94ac-d0cde1729ef6
DOI: 10.64898/2026.06.25.730905

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