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Ground-truth <i>in silico</i> spike-ins reveal limits of microbiome biomarker recovery in colorectal cancer

2026-08-06

Abstract excerpt

Microbiome-based biomarkers have been proposed for colorectal cancer (CRC), yet candidate taxa are often interpreted without knowing whether taxonomic profiling workflows can reliably detect and quantify them in human samples. Existing ground-truth studies commonly rely on simplified communities that do not preserve the biological and technical complexity of clinical stool metagenomes. We hypothesized that weak CR...

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Literature Corpus work
920e1398-fb51-55dc-915a-ceaf8d1d86d6
DOI
10.64898/2026.08.02.742082
Open publication

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Ground-truth <i>in silico</i> spike-ins reveal limits of microbiome biomarker recovery in colorectal cancerDOI 10.64898/2026.08.02.742082
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