Article

KK-LC-1 reveals evolutionary divergence in the regulation of sperm motility between humans and mice

2026-07-17

Abstract excerpt

CT83 (KK-LC-1) is a cancer-testis antigen originally identified in human lung cancer cells and has recently attracted attention as a potential target for cancer therapy. Although KK-LC-1 orthologs have been identified in up to 160 animal species, a murine homolog had not previously been identified, hindering in vivo analysis of its physiological function. In this study, we identified the mouse homolog of KK-LC-1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92095ba4-3e91-506a-b1bc-18e1c1310683
DOI: 10.64898/2026.07.17.739100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KK-LC-1 reveals evolutionary divergence in the regulation of sperm motility between humans and miceDOI 10.64898/2026.07.17.739100Read

Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male FertilitySemantic proximity Read

Nine genes abundantly expressed in the epididymis are not essential for male fecundity in miceSemantic proximity Read

Testis‐specific serine kinase 3 is required for sperm morphogenesis and male fertilitySemantic proximity Read

Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male miceSemantic proximity Read

The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.Semantic proximity Read

WFDC2 gene deletion in mouse led to severe dyspnea and type-I alveolar cell apoptosis.Semantic proximity Read

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesisSemantic proximity Read

FLB1, a Human Protein of Epididymal Origin that is Involved in the Sperm-Oocyte Recognition ProcessSemantic proximity Read

Tektin 3 is required for progressive sperm motility in miceSemantic proximity Read

1 Functional cytology of the human testisSemantic proximity Read

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testisSemantic proximity Read

Kdm4d mutant mice show impaired sperm motility and subfertility.Semantic proximity Read