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Article

Autophagic dysfunction and autophagosome escape in the mdx <i>mus musculus</i> model of Duchenne muscular dystrophy

19 Aug 2017

Abstract excerpt

AIM: Duchenne muscular dystrophy is caused by the absence of functional dystrophin protein and results in a host of secondary effects. Emerging evidence suggests that dystrophic pathology includes decreased pro-autophagic signalling and suppressed autophagic flux in skeletal muscle, but the relationship between autophagy and disease progression is unknown. The purpose of this investigation was to determine the...

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PMID: 28834378
DOI: 10.1111/apha.12944

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