Article

Predicted miRNAs suppressed cell proliferation and migration via FAK/VASP axis; Systems biology approach

2022-01-01

Abstract excerpt

Many studies have reported that some genes in cellular proliferation and migration pathways relate to CRC pathogenesis. The aim of this study was to predict bioinformatically important gene-related miRNAs and investigate experimentally the changes of protein values and gene expression levels, and evaluate the cell proliferation and migration in miRNA/PEI-transfected HT-29 CRC cells. The gene and miRNA networks wer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 919914c6-4a1a-506c-b61a-b5ab05af96c1
DOI: 10.1016/j.imu.2022.100890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predicted miRNAs suppressed cell proliferation and migration via FAK/VASP axis; Systems biology approachDOI 10.1016/j.imu.2022.100890Read

The Expression and Effection of miR-192-5p in colorectal cancer: A Bioinformatic AnalysisSemantic proximity Read

The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancerSemantic proximity Read

Circ4207 regulates vasculogenic mimicry formation in colorectal cancer through the miR-20b-5p/VEGFA axisSemantic proximity Read

Exploring the Diagnostic Potential of miRNAs: A Comprehensive Analysis of miRNA Expression Profiles and Their Correlation with Target Genes in Colorectal CancerSemantic proximity Read

Increased expression of PDGFA and RAF1 in tumor-derived exosomes in human colorectal cancerSemantic proximity Read

miR-125a-5p regulation increases phosphorylation of FAK that contributes to imatinib resistance in gastrointestinal stromal tumorsSemantic proximity Read

New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategiesSemantic proximity Read

Furin sustains tumor-promoting signals in KRAS- and BRAF-mutated colorectal cancer by engaging the TGF-β1–COX-2 axis in a reciprocal regulatory networkSemantic proximity Read

miR-622 inhibits angiogenesis by suppressing the CXCR4–VEGFA axis in colorectal cancerSemantic proximity Read

MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.Semantic proximity Read

MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers.Semantic proximity Read

TIFA Promotes CRC Cell Proliferation via RSK- and PRAS40- Dependent MannerSemantic proximity Read