Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers.

International journal of medical sciences - 1 Jan 2019

Angius Andrea, Pira Giovanna, Scanu Antonio Mario, Uva Paolo, Sotgiu Giovanni, Saderi Laura, Manca Alessandra, Serra Caterina, Uleri Elena, Piu Claudia, Caocci Maurizio, Ibba Gabriele, Zinellu Angelo, Cesaraccio Maria Rosaria, Sanges Francesca, Muroni Maria Rosaria, Dolei Antonina, Cossu-Rocca Paolo, De Miglio Maria Rosaria

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer death worldwide and about 20% is metastatic at diagnosis and untreatable. The anti-EGFR therapy in metastatic patients is led by the presence of KRAS-mutations in tumor tissue. KRAS-wild-type CRC patients showed a positive response rate of about 70% to cetuximab or panitumumab combined with chemotherapy. MiRNAs are promising markers in oncology and could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Cetuximab

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Neoplasm Invasiveness

Share to Neoplasm Proteins

Share to Panitumumab

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 31673240
DOI: 10.7150/ijms.35269
PMCID: PMC6818206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers.PMID 31673240Read ↗

miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progressionSemantic proximity Read ↗

The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancerSemantic proximity Read ↗

The Expression and Effection of miR-192-5p in colorectal cancer: A Bioinformatic AnalysisSemantic proximity Read ↗

Let-7c-5p Down Regulates the Proliferation of Colorectal Cancer Through the MAPK-ERK-Signaling PathwaySemantic proximity Read ↗

miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study.Semantic proximity Read ↗

MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers.Semantic proximity Read ↗

The role of miRNA-424 in various cancers: Focusing on drug resistance and sensitivitySemantic proximity Read ↗

Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acidsSemantic proximity Read ↗

miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma.Semantic proximity Read ↗

Long noncoding RNA MAPKAPK5‐AS1 promotes colorectal cancer proliferation by partly silencing p21 expressionSemantic proximity Read ↗

Expression of miR-200c and its clinicopathological significance in patients with colorectal cancer.Semantic proximity Read ↗

Understanding microRNA-Mediated Chemoresistance in Colorectal Cancer TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.