Article

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

2021-02-03

Abstract excerpt

The immune system of most SARS-CoV-2 infected individuals limits viral spread to the upper airways without pulmonary involvement. This prevents the development of pneumonic COVID-19. However, the protective immunological responses causative of successful viral containment in the upper airways remain unclear. Here, we combine longitudinal single-cell RNA sequencing, proteomic profiling, multidimensional flow c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 917de4c3-ddb3-5dcf-b1b6-6dadee183644
DOI: 10.1101/2021.02.03.429351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infectionDOI 10.1101/2021.02.03.429351Read

Protective Immune Trajectories in Early Viral Containment of Non-Pneumonic SARS-CoV-2 InfectionSemantic proximity Read

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenSemantic proximity Read

Cell specific peripheral immune responses predict survival in critical COVID-19 patientsSemantic proximity Read

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approachesSemantic proximity Read

Dysregulated transcriptional responses to SARS-CoV-2 in the peripherySemantic proximity Read

Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory virusesSemantic proximity Read

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2Semantic proximity Read

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunitySemantic proximity Read

Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumoniaSemantic proximity Read

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2Semantic proximity Read

Immune perturbations induced by SARS-CoV2 in infants vary with disease severity and differ from adults’ responsesSemantic proximity Read

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcomeSemantic proximity Read