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Orally Antigen-Engineered Yeast Vaccine Elicits Robust Intestinal Mucosal Immunity

13 Mar 2025

Abstract excerpt

Mucosal immunity plays a pivotal role in safeguarding against significant global infectious diseases caused by mucosal pathogens. The development of mucosal vaccines has been limited by the poor efficiency of antigen display and the risk of adjuvants. Here, we report an engineered yeast vaccine integrating a well-displayed antigen with an intrinsic adjuvant for the development of innate and adaptive immunity to...

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PMID: 40082064
DOI: 10.1021/acsnano.4c14690

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