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Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

1 Jul 2024

Abstract excerpt

BACKGROUND: Fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT, sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile infections, possibly through bacteriophage-mediated modulation of the gut microbiome. However, challenges like donor variability, costly screening, coupled with concerns over pathogen transfer (incl. eukaryotic viruses) with FMT...

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PMID: 38951925
DOI: 10.1186/s40168-024-01820-1

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