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Article

Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials

10 Apr 2007

Abstract excerpt

AIMS: To construct a genetically modified strain of Streptococcus mutans for dental caries prevention. The strain has significantly reduced cariogenicity owing to a deletion of the entire open reading frame for lactate dehydrogenase, and has excellent colonization potential through the production of a natural antibiotic called mutacin 1140. For use in human clinical trials, additional mutations were introduced to...

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PMID: 17448156
DOI: 10.1111/j.1365-2672.2007.03316.x

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