Article

Exosomes from bone marrow mesenchymal stem cells promoted osteogenic differentiation by delivering miR-196a that targeted Dkk1 to activate Wnt/β-catenin pathway

2020-05-05

Abstract excerpt

<title>Abstract</title> <p>Background: Osteoporosis is the most common bone metabolic disease. Emerging evidence suggests that exosomes are secreted by diverse cells such as bone marrow mesenchymal stem cells (BMSCs), and play important role in cell-to-cell communication and tissue homeostasis. Recently, the discovery of exosomes has attracted attention in the field of bone remodeling. <h4>Methods:</h4> The exos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91236c15-dc54-594e-947d-fedb7febe44e
DOI: 10.21203/rs.3.rs-25044/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exosomes from bone marrow mesenchymal stem cells promoted osteogenic differentiation by delivering miR-196a that targeted Dkk1 to activate Wnt/β-catenin pathwayDOI 10.21203/rs.3.rs-25044/v1Read

The role and mechanism of exosomes from umbilical cord mesenchymal stem cells in inducing osteogenesis and preventing osteoporosisSemantic proximity Read

Exosomes and Bone DiseaseSemantic proximity Read

Exosomal miRNA-21-5p derived from bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion by targeting PIK3R1Semantic proximity Read

miR-219a-5p Suppresses GSK-3β/β-catenin Signaling to Influence BMSC OsteogenesisSemantic proximity Read

MiR-486-3p promotes osteogenic differentiation of BMSCs by targeting CTNNBIP1 and activating Wnt/β-catenin pathwaySemantic proximity Read

The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and DiseaseSemantic proximity Read

Human dental pulp stem cell-derived exosomes inhibit adipogenesis and obesity by activating Wnt/β-catenin signalingSemantic proximity Read

Nanoparticles Delivering Antagomir-483-5p to Bone Marrow Mesenchymal Stem Cells Prevent Osteoporosis by Increasing Bone FormationSemantic proximity Read

Mir-4699 Promotes the Osteogenic Differentiation of Mesenchymal Stem CellsSemantic proximity Read

Diabetic and nondiabetic BMSC–derived exosomes affect bone regeneration via regulating miR-17-5p/SMAD7 axisSemantic proximity Read

Bone marrow mesenchymal stem cell-derived exosomal microRNA-382 promotes osteogenesis in osteoblast via regulation of SLIT2Semantic proximity Read

Knockdown of FOXA1 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the ERK1/2 signalling pathwaySemantic proximity Read