Article

Exosomal miRNA-21-5p derived from bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion by targeting PIK3R1

2020-12-10

Abstract excerpt

Mesenchymal stem cells (MSCs) are a class of pluripotent cells that can release a large number of exosomes which act as paracrine mediators in tumor associated microenvironment. However, the role of MSC-derived exosomes in pathogenesis and progression of cancer cells especially osteosarcoma has not yet been thoroughly clarified until now. In this study, we established a co-culture model for human bone marrow deriv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6569a022-1c96-56d6-9a42-c8d0af4f0cd5
DOI: 10.21203/rs.3.rs-120370/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exosomal miRNA-21-5p derived from bone marrow mesenchymal stem cells promote osteosarcoma cell proliferation and invasion by targeting PIK3R1DOI 10.21203/rs.3.rs-120370/v1Read

A Comprehensive Cancer-Associated MicroRNA Expression Profiling and Proteomic Analysis of Human Umbilical Cord Mesenchymal Stem Cell-Derived ExosomesSemantic proximity Read

CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcomaSemantic proximity Read

Exosomal PD-L1 Derived From Osteosarcoma is Associated With Pulmonary Metastasis for Patients With OsteosarcomaSemantic proximity Read

Exosomes from bone marrow mesenchymal stem cells promoted osteogenic differentiation by delivering miR-196a that targeted Dkk1 to activate Wnt/β-catenin pathwaySemantic proximity Read

Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte functionSemantic proximity Read

Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.Semantic proximity Read

Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cellsSemantic proximity Read

Dual Role of MSC-Derived Exosomes in Tumor DevelopmentSemantic proximity Read

A comprehensive cancer-associated microRNA expression profiling and proteomic analysis of human umbilical cord mesenchymal stem cell derived exosomes.Semantic proximity Read

<i>LINC00968</i> functions as an oncogene in osteosarcoma by activating the PI3K/AKT/mTOR signalingSemantic proximity Read

miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 ModulationSemantic proximity Read

Exosomal miR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in OsteosarcomaSemantic proximity Read