Article

FGF21 defines a potential cardio-hepatic signaling circuit in human heart failure

2021-07-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Extrinsic control of cardiac contractility and ultrastructure via neurohormonal signaling is well established, but how other organs regulate cardiomyocyte metabolism is less well understood. Fibroblast growth factor-21 (FGF21) a hormonal regulator of metabolism mainly produced in the liver and adipose tissue, is a prime candidate for such signaling. <h4>Methods</h4> To investi...

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Literature Corpus work: 91076b1f-b18a-58d8-bb9b-f025c09c9345
DOI: 10.1101/2021.06.29.21259720

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