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Article

Preservation of circadian rhythms by the protein folding chaperone, BiP

2018-06-15

Abstract excerpt

ER stress and dysregulation of collagen synthesis are associated with progression of disease in cancer and fibrosis. Collagen synthesis is co-ordinated with the circadian clock, which curiously in cancer cells, is deregulated by ER stress. We hypothesised that interplay exists between circadian rhythm, collagen synthesis and ER stress in normal cells. Here we show that fibroblasts with ER stress do not demonstrate...

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Identifiers and source

Literature Corpus work
90e47ae5-4eb6-57cb-afc3-03004c5f04a1
DOI
10.1101/348078
Open publication

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