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Article

The unfolded protein response and its relevance to connective tissue diseases

22 Oct 2009

Abstract excerpt

The unfolded protein response (UPR) has evolved to counter the stresses that occur in the endoplasmic reticulum (ER) as a result of misfolded proteins. This sophisticated quality control system attempts to restore homeostasis through the action of a number of different pathways that are coordinated in the first instance by the ER stress-senor proteins IRE1, ATF6 and PERK. However, prolonged ER-stress-related UPR...

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PMID: 19851784
DOI: 10.1007/s00441-009-0877-8

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