Article

In-silico immune cell deconvolution of the airway proteomes of infants with pneumonia reveals a link between reduced airway eosinophils and an increased risk of mortality

2019-11-13

Abstract excerpt

<h4>Rationale</h4> Pneumonia is a leading cause of mortality in infants and young children. The mechanisms that lead to mortality in these children are poorly understood. Studies of the cellular immunology of the infant airway have traditionally been hindered by the limited sample volumes available from the young, frail children who are admitted to hospital with pneumonia. This is further compounded by the relati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90dd7076-16b4-59a8-a60a-dfd94a1d8f69
DOI: 10.1101/840090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In-silico immune cell deconvolution of the airway proteomes of infants with pneumonia reveals a link between reduced airway eosinophils and an increased risk of mortalityDOI 10.1101/840090Read

Application of high dimensional flow cytometry and unsupervised analysis to define the immune cell landscape of early childhood respiratory and blood compartmentsSemantic proximity Read

Analyzing and validating diagnostic biomarkers and immune cell infiltration characteristics in ALI/ARDS models using bioinformatics and machine learningSemantic proximity Read

Pathogen-specific host responses define distinct pneumonia endotypes in the human lungSemantic proximity Read

Developing an Early Diagnostic Signature and Deciphering the Microbial-Host Dynamics in Lower Respiratory Tract Infection (LRTI) in Paediatric Intensive Care Unit (PICU) PatientsSemantic proximity Read

Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infectionsSemantic proximity Read

Machine learning-based derivation and validation of three immune phenotypes for risk stratification and prognosis in community-acquired pneumonia: a retrospective cohort study.Semantic proximity Read

Distinct clinical phenotypes and outcomes in pediatric chronic eosinophilic pneumonia: a 12- year retrospective cohort study.Semantic proximity Read

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.Semantic proximity Read

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumoniaSemantic proximity Read

Human Biomarker Discovery and Predictive Models for Disease Progression for Idiopathic Pneumonia Syndrome Following Allogeneic Stem Cell TransplantationSemantic proximity Read

Proteomic profiling of bronchoalveolar lavage fluid uncovers protein clusters linked to survival in idiopathic forms of interstitial lung diseaseSemantic proximity Read

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypesSemantic proximity Read