Anti-inflammatory and Antioxidant Effect of Poly-Gallic Acid (PGAL) in an in vitro Model of Synovitis Induced by Monosodium Urate Crystals

Abstract excerpt

<title>Abstract</title> <p>Gout is a chronic and degenerative disease that affects the joints and soft tissues because of the crystalline deposit of monosodium urate. The interaction between monosodium urate crystals (MSU) and synoviocytes generates oxidative and inflammatory states. These physiological characteristics have promoted the study of Poly-gallic acid (PGAL), a poly-oxidized form of gallic acid reporte...

Topics

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• Anti-Inflammatory Agents
• Inflammasomes
• Macrophages
• MicroRNAs
• NF-kappa B
• NLR Family, Pyrin Domain-Containing 3 Protein
• STAT3 Transcription Factor
• Uric Acid

Identifiers and source

Literature Corpus work

2c478d28-bcc6-510c-87c8-44a8bb3497ac

DOI

10.21203/rs.3.rs-1316095/v1