Article

Anti-inflammatory and Antioxidant Effect of Poly-Gallic Acid (PGAL) in an in vitro Model of Synovitis Induced by Monosodium Urate Crystals

2022-02-04

Abstract excerpt

<title>Abstract</title> <p>Gout is a chronic and degenerative disease that affects the joints and soft tissues because of the crystalline deposit of monosodium urate. The interaction between monosodium urate crystals (MSU) and synoviocytes generates oxidative and inflammatory states. These physiological characteristics have promoted the study of Poly-gallic acid (PGAL), a poly-oxidized form of gallic acid reporte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c478d28-bcc6-510c-87c8-44a8bb3497ac
DOI: 10.21203/rs.3.rs-1316095/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-inflammatory and Antioxidant Effect of Poly-Gallic Acid (PGAL) in an in vitro Model of Synovitis Induced by Monosodium Urate CrystalsDOI 10.21203/rs.3.rs-1316095/v1Read

Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis.Semantic proximity Read

Pentagalloyl glucose Suppresses MSU Crystal–Induced Gout Inflammation and Arachidonic Acid Production In Vitro and In VivoSemantic proximity Read

Monosodium Urate Crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory responseSemantic proximity Read

l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes.Semantic proximity Read

Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process.Semantic proximity Read

Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in goutSemantic proximity Read

Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro.Semantic proximity Read

MiR‐223‐3p and miR‐22‐3p inhibit monosodium urate‐induced gouty inflammation by targeting NLRP3Semantic proximity Read

The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosisSemantic proximity Read

Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophagesSemantic proximity Read

Oxidative stress and the viability of osteoblasts and cerebellar granule neuronesSemantic proximity Read

Impact of sugars on kidney stone formationSemantic proximity Read