Article

Machine learning-assisted neurotoxicity prediction in human midbrain organoids

2019-09-19

Abstract excerpt

A major challenge in the field of neurodegenerative diseases is the poor translation of pre-clinical models to clinical applications. The human brain is an immensely complex structure, which makes it difficult to recapitulate its development, function and disorders. In the recent years, brain organoids derived from human induced pluripotent stem cells have risen as novel tools to study neurodegenerative diseases s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 907fd886-6ae2-5c2e-91f9-9e014c8dc4d4
DOI: 10.1101/774240

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Machine learning-assisted neurotoxicity prediction in human midbrain organoidsDOI 10.1101/774240Read

Brain Organoids in Parkinson’s Disease Drug Development: Human-Specific Models for Translational DiscoverySemantic proximity Read

Mosaic midbrain organoids: a new tool to study Progressive Supranuclear Palsy and advancing clinical neurology researchSemantic proximity Read

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.Semantic proximity Read

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modelingSemantic proximity Read

NEUBOrg: artificially induced pluripotent stem cell-derived brain organoid to model and study genetics of Alzheimer’s disease progression.Semantic proximity Read

Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modellingSemantic proximity Read

Modelling neurodegenerative disease using brain organoids.Semantic proximity Read

Modeling neurological disorders using brain organoids.Semantic proximity Read

iPSCs and Organoids in Advancing Neuropathology Research and TherapiesSemantic proximity Read

Released mitochondrial DNA and neurofilament light chain as Parkinson’s disease phenotypes in patient-specific midbrain assembloidsSemantic proximity Read

Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity Read

Development of a multi-sensor integrated midbrain organoid-on-a-chip platform for studying Parkinson’s diseaseSemantic proximity Read