Article

Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677

2021-02-14

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) plays critical roles in host cell entry. Non-synonymous substitutions affecting S are not uncommon and have become fixed in a number of SARS-CoV-2 lineages. A subset of such mutations enable escape from neutralizing antibodies or are thought to enhance transmission through mechanisms such as increased affinity for the cell entry rec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 907e1b95-79cd-5cfa-b52c-b0dbcaa9b705
DOI: 10.1101/2021.02.12.21251658

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677DOI 10.1101/2021.02.12.21251658Read

Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations.Semantic proximity Read

Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants.Semantic proximity Read

Mutations and Evolution of the SARS-CoV-2 Spike Protein.Semantic proximity Read

Preliminary report on SARS-CoV-2 Spike mutation T478KSemantic proximity Read

Convergent Evolution in SARS-CoV-2 Spike Creates a Variant Soup from Which New COVID-19 Waves EmergeSemantic proximity Read

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies.Semantic proximity Read

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwideSemantic proximity Read

Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive Advantage.Semantic proximity Read

Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwideSemantic proximity Read

Expanding repertoire of SARS-CoV-2 deletion mutations contributes to evolution of highly transmissible variants.Semantic proximity Read

Making sense of spike D614G in SARS-CoV-2 transmission.Semantic proximity Read

Preliminary report on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike mutation T478K.Semantic proximity Read