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Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations.

Emerging microbes & infections - 1 Dec 2021

Shen Lishuang, Bard Jennifer Dien, Triche Timothy J, Judkins Alexander R, Biegel Jaclyn A, Gai Xiaowu

Abstract excerpt

The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) protein, and a few other mutations. These include two mutations in the N terminal domain (NTD) of the S protein, HV69-70del and Y144del (also known as Y145del due to the...

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Identifiers

PMID: 34125658
DOI: 10.1080/22221751.2021.1943540
PMCID: PMC8238060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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