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Article

Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants.

Journal of clinical microbiology - 19 Oct 2021

Tchesnokova Veronika, Kulasekara Hemantha, Larson Lydia, Bowers Victoria, Rechkina Elena, Kisiela Dagmara, Sledneva Yulia, Choudhury Debarati, Maslova Iryna, Deng Kai, Kutumbaka Kirthi, Geng Hao, Fowler Curtis, Greene Dina, Ralston James, Samadpour Mansour, Sokurenko Evgeni

Abstract excerpt

We report that there is a recent global expansion of numerous independent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the receptor-binding domain (RBD) of the spike protein. The massive emergence of L452R variants was first linked to lineage B.1.427/B.1.429 (clade 21C) that has been spreading in California since November and December 2020, originally named CAL.20C...

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Identifiers

PMID: 34379531
DOI: 10.1128/JCM.00921-21
PMCID: PMC8525575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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