Article

Single Cell Resolution Spatial Mapping of Human Hematopoiesis Reveals Aging-Associated Topographic Remodeling

2023-04-30

Abstract excerpt

<h4>ABSTRACT</h4> The spatial anatomy of hematopoiesis in bone marrow has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain thousands of paraffinized bone marrow core biopsy tissue specimens, providing a rich resource for studying the intact human bone marrow topography in a variety...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 905aef73-41ca-5c58-a486-32ffce21905a
DOI: 10.1101/2023.04.28.538715

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single Cell Resolution Spatial Mapping of Human Hematopoiesis Reveals Aging-Associated Topographic RemodelingDOI 10.1101/2023.04.28.538715Read

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic ImagingSemantic proximity Read

Adult skull bone marrow is an expanding and resilient hematopoietic reservoirSemantic proximity Read

Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysisSemantic proximity Read

Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-Driven MonopoiesisSemantic proximity Read

Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and AgingSemantic proximity Read

Single-cell profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrowSemantic proximity Read

Molecular Deconvolution of Bone Marrow Adipose Tissue Interactions with Malignant Hematopoiesis: Potential for New Therapy DevelopmentSemantic proximity Read

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human OrgansSemantic proximity Read

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environmentSemantic proximity Read

Structural organization of the bone marrow and its role in hematopoiesisSemantic proximity Read

Single-cell and spatial transcriptomics approaches of the bone marrow microenvironmentSemantic proximity Read

Changing landscape of hematopoietic and mesenchymal cells and their interactions during aging and in age-related skeletal pathologiesSemantic proximity Read