Article
APOE-guided lecanemab dosing dissociates ARIA-E from ARIA-H: The K-ROAD study.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2026
Kang Heekyoung, Jang Hyemin, Ahn Jehyun, Na Duk L, Lee Jae-Hong, Kim Eun-Joo, Chun Min Young, Cho Soo Hyun, Kim Byeong C, Kim Si Eun, Sohn Gyeongmo, Yun Jihwan, Lee Jin San, Park Key-Chung, Park Hee Kyung, Kim Young Ju, Lee Kyungbok, Yim Sohyun, Kim Seonghyeon, Kim Jun Pyo, Kim Hee Jin, Lim Jae-Sung, Seo Sang Won
Abstract excerpt
INTRODUCTION: We evaluated whether apolipoprotein E (APOE εε4) genotype-guided lecanemab escalation mitigates the APOE εε4-driven amyloid-related imaging abnormalities (ARIA) with edema (ARIA-E) gradient and whether ARIA-E and ARIA with hemosiderin deposition (ARIA-H) are mechanistically distinct. METHODS: Five hundred eight patients with early Alzheimer's disease received APOE genotype-guided lecanemab...
Topics
Join the communities discussing this publication.