Article

A crypt-operating DNA repair checkpoint for uncoupling regeneration and tumorigenesis

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> The rapid turnover of the intestinal epithelium increases its vulnerability to genomic instability and environmental insults such as irradiation. Defects in DNA damage resolution can compromise epithelial regeneration, promote chronic tissue injury, and predispose to colorectal tumorigenesis. However, the intrinsic mechanisms that coordinate DNA repair with epithelial regeneration at the crypt l...

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Literature Corpus work: 8ffdbc52-f24a-5259-871b-efc38a0e9fbc
DOI: 10.64898/2026.02.27.708480

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