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Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer.

Gastroenterology - 1 Jul 2021

Bui Triet M, Butin-Israeli Veronika, Wiesolek Hannah L, Zhou Meredith, Rehring Jake F, Wiesmüller Lisa, Wu Jennifer D, Yang Guang-Yu, Hanauer Stephen B, Sebag Julien A, Sumagin Ronen

Abstract excerpt

BACKGROUND & AIMS: Tumor-infiltrating neutrophils (polymorphonuclear neutrophils [PMNs]) are a prominent feature of colorectal cancer (CRC), where they can promote cytotoxicity or exacerbate disease outcomes. We recently showed that in acute colon injury, PMNs can increase DNA double-strand break (DSB) burden and promote genomic instability via microRNA-dependent inhibition of homologous recombination (HR)...

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PMID: 33753103
DOI: 10.1053/j.gastro.2021.03.027

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