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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite <i>Plasmodium falciparum</i> via Polypharmacological Inhibition of <i>Pf</i> Ark1 and Hemozoin Formation

2025-07-17

Abstract excerpt

The high burden of malaria and growing resistance to frontline antimalarials demand new drug target combinations with reduced propensities for conferring parasite resistance. An attractive approach for circumventing antimalarial drug resistance is target repurposing in which known drugs that act through protein targets of human origin that are also active against the human malaria parasite Plasmodium falciparum a...

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Literature Corpus work
8ff069a0-f5db-5b41-8414-3d62db097c40
DOI
10.1101/2025.07.17.664511
Open publication

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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against the Human Malaria Parasite <i>Plasmodium falciparum</i> via Polypharmacological Inhibition of <i>Pf</i> Ark1 and Hemozoin FormationDOI 10.1101/2025.07.17.664511
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