Article

A method for measuring mitochondrial DNA copy number in pediatric populations

2024-03-21

Abstract excerpt

The mitochondrion is a multifunctional organelle that modulates multiple systems critical for homeostasis during pathophysiological stress. Variation in mitochondrial DNA (mtDNA) copy number (mtDNAcn), a key mitochondrial change associated with chronic stress, is an emerging biomarker for disease pathology and progression. mtDNAcn can be quantified from whole blood samples using qPCR to determine the ratio of nucl...

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Literature Corpus work: 8fcc8df2-8801-5e94-a299-88e013cf3241
DOI: 10.1101/2024.03.19.24304372

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