Article
Breast Cancer Neoantigens Can Induce CD8+ T-Cell Responses and Antitumor Immunity.
Cancer immunology research - 1 Jul 2017
Zhang Xiuli, Kim Samuel, Hundal Jasreet, Herndon John M, Li Shunqiang, Petti Allegra A, Soysal Savas D, Li Lijin, McLellan Mike D, Hoog Jeremy, Primeau Tina, Myers Nancy, Vickery Tammi L, Sturmoski Mark, Hagemann Ian S, Miller Chris A, Ellis Matthew J, Mardis Elaine R, Hansen Ted, Fleming Timothy P, Goedegebuure S Peter, Gillanders William E
Abstract excerpt
Next-generation sequencing technologies have provided insights into the biology and mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in human breast cancers. Using patient-derived xenografts from three patients with advanced breast cancer (xenografts were designated as WHIM30, WHIM35, and WHIM37), we sequenced exomes of tumor and patient-matched normal cells. We identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.