Article

Downregulation of ALDH5A1 Promotes Tumor Metastasis and Contributes to Poor Prognosis in Ovarian Cancer

2020-01-31

Abstract excerpt

<title>Abstract</title> <p>Background Despite modern therapies, ovarian cancer (OC) remains a major clinical problem with a high risk of mortality. We previously reported that low expression of ALDH5A1 could serve as an indicator for predicting poor prognosis in OC. However, the function of ALDH5A1 in OC progression has not been elucidated yet. Methods We firstly compared ALDH5A1 expression in metastatic tissues...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb42cf78-c2e6-5600-a713-207971e5f94e
DOI: 10.21203/rs.2.22370/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Downregulation of ALDH5A1 Promotes Tumor Metastasis and Contributes to Poor Prognosis in Ovarian CancerDOI 10.21203/rs.2.22370/v1Read

ANGPTL4-ETV5-CDH5 Signaling Axis: A Novel Pathway Driving Metastasis in Ovarian CancerSemantic proximity Read

Decreased expression of ALDH5A1 predicts prognosis in patients with ovarian cancer.Semantic proximity Read

The role of OIP5 in the carcinogenesis and progression of ovarian cancerSemantic proximity Read

Construction and validation of an anoikis-related gene prognostic signature in ovarian cancerSemantic proximity Read

LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoterSemantic proximity Read

ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathwaySemantic proximity Read

MUM1L1 as a Tumor Suppressor and Potential Biomarker in Ovarian Cancer: Evidence from Bioinformatics Analysis and Basic ExperimentsSemantic proximity Read

Silencing of Epidermal Growth Factor-like Domain 8 Promotes Proliferation and Cancer Aggressiveness in Human Ovarian Cancer Cells by Activating ERK/MAPK Signaling CascadesSemantic proximity Read

Screening key genes related to ovarian cancer and exploring their possible molecular mechanismsSemantic proximity Read

Validation of ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic SignificanceSemantic proximity Read

A novel risk score system for assessment of ovarian cancer based on co-expression network analysis and expression level of five lncRNAsSemantic proximity Read

Mitophagy-related long non-coding RNA signature predicts prognosis and drug response in Ovarian CancerSemantic proximity Read