Article

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

2022-10-14

Abstract excerpt

<h4>ABSTRACT</h4> The worldwide pandemic caused by SARS-CoV-2 has remained a human medical threat due to the continued evolution of multiple variants that acquire resistance to vaccines and prior infection. Therefore, it is imperative to discover monoclonal antibodies (mAbs) that neutralize a broad range of SARS-CoV-2 variants for therapeutic and prophylactic use. A stabilized autologous SARS-CoV-2 spike glycopro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f17c4e3-d149-523a-a739-466623015c52
DOI: 10.1101/2022.10.14.512216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected IndividualDOI 10.1101/2022.10.14.512216Read

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infectionSemantic proximity Read

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron VariantsSemantic proximity Read

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domainSemantic proximity Read

Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 Variants.Semantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infectionSemantic proximity Read

Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants.Semantic proximity Read

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernSemantic proximity Read

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variantsSemantic proximity Read

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding propertiesSemantic proximity Read

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe diseaseSemantic proximity Read

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clonesSemantic proximity Read

Shared N417-dependent epitope on the SARS-CoV-2 Omicron, Beta and Delta-plus variantsSemantic proximity Read