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Article

Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

9 Oct 2019

Abstract excerpt

Abstract N 6 -methyladenosine (m 6 A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m 6 A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of m 6 A methyltransferases decreases RSV replication and gene expression whereas knockdown of m 6 A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31597913
DOI: 10.1038/s41467-019-12504-y

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