Article

SMCHD1 maintains heterochromatin and genome compartments in human myoblasts

2024-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian genomes are subdivided into euchromatic A compartments that contain mostly active chromatin, and inactive, heterochromatic B compartments. However, it is unknown how A and B genome compartments are established and maintained. Here we studied SMCHD1, an SMC-like protein in human male myoblasts. SMCHD1 colocalizes with Lamin B1 and the heterochromatin mark H3K9me3. Loss of SMCHD1 leads t...

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Literature Corpus work: 8edbeb04-232a-5fd1-8659-78578c78d53b
DOI: 10.1101/2024.07.07.602392

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