Article

SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells

2026-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Human SMCHD1 (Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1) is a chromatin architectural protein linked to heterochromatin repression. Loss of function mutations of SMCHD1 cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) through activation of the DUX4 homeobox transcription factor gene. However, it is unknown how SMCHD1 may regulate myogenic transcription...

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Literature Corpus work: 84a53f67-78ce-521b-a25c-845cd3721ba9
DOI: 10.64898/2026.02.21.707202

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