Article

SMCHD1 activates the expression of genes required for the expansion of human myoblasts

2024-02-04

Abstract excerpt

<h4>ABSTRACT</h4> SMCHD1 is an epigenetic regulatory protein known to modulate the targeted repression of large chromatin domains. Diminished SMCHD1 function in muscle fibers causes Facioscapulohumeral Muscular Dystrophy (FSHD2) through derepression of the D4Z4 chromatin domain, an event which permits the aberrant expression of the disease-causing gene DUX4 . Given that SMCHD1 plays a broader role in establishi...

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Literature Corpus work: 033a973e-45a2-56e4-b010-2bfb3aed3da5
DOI: 10.1101/2024.02.04.578809

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