MORT, a locus for apoptosis in the human immunodeficiency virus-type 1 antisense gene: implications for AIDS, Cancer, and Covid-19

Abstract excerpt

Apoptosis, or programmed cell death, is a fundamental requirement for life in multicellular organisms, including humans, and a mechanism to maintain homeostasis and prevent unwarranted cellular proliferations such as cancer. An antisense gene in HIV-1 ( Hap ) induces apoptosis in human cells. Apoptotic T cell death following HIV-1 infection leads to a compromised immune system and eventually AIDS (acquired immuno...

Topics

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• Cell death mechanisms and regulation
• Gene Expression Regulation, Viral
• Hepatitis B Virus Studies
• HIV Long Terminal Repeat
• HIV Research and Treatment
• Leukocytes, Mononuclear
• NF-kappa B
• Nucleic Acid Conformation

Identifiers and source

Literature Corpus work

8ec5481f-6ca6-5c8d-8112-4fb342ae127b

DOI

10.1101/2020.07.01.180828