Article
Unraveling the genetic landscape of ALS in Greece: identification of known and novel causative variants in a 353-patient cohort.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 May 2026
Kartanou Chrisoula, Kontogeorgiou Zoi, Loupis Theodoros, Vrachnos Dimitrios M, Ragazos Nikolaos, Spyropoulou Ifigenia, Petraki Maria, Koniari Chrysoula, Aristeidou Stavroula, Koropouli Eleftheria, Daponte Ariadne, Rentzos Michail, Kapaki Elisabeth, Panas Marios, Makrythanasis Periklis, Stefanis Leonidas, Koutsis Georgios, Karadima Georgia
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult-onset, progressive, fatal neurodegenerative disorder characterized by progressive loss of motor neurons. Approximately 15% of individuals diagnosed with ALS have a known genetic variant that contributes to disease. Herein, we present clinical and genetic data of a large Greek ALS cohort. PATIENTS AND METHODS: The cohort consisted of 353 Greek consecutive...
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