Article

A Physiologically Constrained Calibration Framework for Cardiovascular Models applied in Paediatric Sepsis

2026-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Calibration of mechanistic cardiovascular models is a central barrier to their use in population analysis and patient-specific simulation, particularly in settings where key physiological variables are unobservable and multiple parameter combinations can reproduce the same haemodynamic targets. In this work, we present Embedded Gradient Descent (EGD), a calibration framework for ODE-based lumped...

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Literature Corpus work: 8e2a4172-5cf0-5d34-88b6-9e925f01bfd1
DOI: 10.64898/2026.02.10.704842

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