Article

Physiology-Informed Conditional Variational Autoencoder for Generating Pediatric Virtual Patients

2026-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Reliable pediatric virtual patients are essential for model-informed simulations, including physiologically based pharmacokinetic (PBPK) modeling, to support dose selections in children and to evaluate drug exposure across developmental stages. Despite the availability of extensive pediatric physiological data and age- or size-based models, there remains a lack of well-established, flexible, and...

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Literature Corpus work: a6c47f7f-417d-590f-a6ae-6871750a02a1
DOI: 10.64898/2026.01.21.26344442

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