Article

Structural Insights into the Interaction Between Adenovirus C5 Hexon and Human Lactoferrin

2023-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Adenovirus (AdV) infection of the respiratory epithelium is common, but poorly understood. Human AdV species C types, such as HAdV-C5, utilize the Coxsackie-adenovirus receptor (CAR) for attachment and subsequently integrins for entry. CAR and integrins are however located deep within the tight junctions in the mucosa where they would not be easily accessible. Recently, a model for CAR-independe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e298957-aefd-57c7-92a7-726bf6c9bb4f
DOI: 10.1101/2023.10.09.561496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Insights into the Interaction Between Adenovirus C5 Hexon and Human LactoferrinDOI 10.1101/2023.10.09.561496Read

Structural insights into the interaction between adenovirus C5 hexon and human lactoferrin.Semantic proximity Read

Adenoviruses Use Lactoferrin as a Bridge for CAR-Independent Binding to and Infection of Epithelial CellsSemantic proximity Read

The structure of the Human Adenovirus 7 virus-like particles reveals that pentons and core-genome promote hexon-pIIIa interactions during capsid maturationSemantic proximity Read

Cryo-EM structure of enteric adenovirus HAdV-F41 highlights structural variations among human adenovirusesSemantic proximity Read

Adenovirus Type 6: Subtle Structural Distinctions from Adenovirus Type 5 Result in Essential Differences in Properties and Perspectives for Gene TherapySemantic proximity Read

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactionsSemantic proximity Read

An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5Semantic proximity Read

Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenovirusesSemantic proximity Read

Human adenovirus binding to host cell receptors: a structural viewSemantic proximity Read

Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory CellsSemantic proximity Read

Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residuesSemantic proximity Read

Atomic Structures of Minor Proteins VI and VII in Human AdenovirusSemantic proximity Read