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Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses

5 May 2017

Abstract excerpt

Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases and are also frequently used as gene and vaccine delivery vectors. Unlike the archetype human adenovirus C5 (HAdV-C5), human adenovirus D26 (HAdV-D26) belongs to species-D HAdVs, which target different cellular receptors, and is differentially recognized by immune surveillance mechanisms. HAdV-D26 is being championed as a lower...

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PMID: 28508067
DOI: 10.1126/sciadv.1602670

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